Pregabalin CAS 148553-50-8

Short Description:

Pregabalin is a new antiepileptic drug, having a γ-amino butyric acid structure on its molecular structure, which has anticonvulsant effects.

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Product Detail

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Description

Pregabalin is a new antiepileptic drug, having a γ-amino butyric acid structure on its molecular structure, which has anticonvulsant effects.

Specification:

Product Name	Pregabalin
CAS No.	148553-50-8
Purity	99%
Molecular Formula	C8H17NO2
Molecular Weight	159.23
Melting point	194-196°C
Density	0.997±0.06 g/cm3(Predicted)
Appearance	White crystal powder
Grade	Pharmaceutical grade
Category	Active Pharmaceutical Ingredient (API)
Drug Class	Anticonvulsant - GABA Analogs · Diabetic Peripheral Neuropathy Agents · Fibromyalgia Agents - GABA Analogs · Neuropathic Pain Therapy · Postherpetic Neuralgia Agents
Brand	SHXLCHEM

Technical Data Sheet/TDS:

Description	White to off white crystalline powder
Indentification color reaction	Ninhydrin reaction solution is blue purple
Indentification by IR	IR spectrum is consistent with reference standard
Solubility	Sparingily soluble in water sightly
Specific optical rotation	Between +8.5°to +12.0°
Related substance by HPLC (-) Amide	Not more than 0.15%
4E	Not more than 0.15%
5E	Not more than 0.15%
Lactum	Not more than 0.15%
Unknown impurity	Not more than 0.15%
Total impurity	Not more than 0.15%
Heavy metals	Not more than 200ppm
Sulphated ash	Not more than 0.1% w/w
Loss on drying	Not more than 0.5% w/w
Methanol	Not more than 3000ppm
Toluene	Not more than 890ppm
N-butanol	Not more than 5000ppm
Ethyl acetate	Not more than 5000ppm
Chloroform	Not more than 60ppm
N-hexane	Not more than 290ppm
Emantiomeric purity by HPLC R-Pregabalin content	Not more than 0.15% of the area of R-Pregabalin
Assay by HPLC ( on dried basis)	Not more than 98.0 w/w and Not more than 102.0% w/w

Application

Pregabalin is an Active Pharmaceutical Ingredient (API), usually used to kill pain caused by nerve damage due to diabetes, shingles (herpes zoster) infection, or spinal cord injury. Pregabalin also used to treat pain in people with fibromyalgia. It is also used with other medications to treat certain types of seizures (focal seizures).